This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports. Week 2 gets underway with two of the NFL’s most exciting offenses facing off, as the Buffalo Bills host the Detroit Lions on Thursday Night Football. New users can use bet365 Bonus Code FOX365 to unlock $365 in bonuses and follow Josh Allen, Jahmyr Gibbs and two explosive offenses as the NFL’s second week officially begins. Allen started his 2026 campaign accounting for 357 yards and four touchdowns in Buffalo’s Week 1 win against Houston. Bills’ new receiver DJ Moore was Allen’s favorite target last week. Moore had 100 yards and a touchdown on five catches. Detroit needed all of Jahmyr Gibbs’ and Amon-Ra St. Brown’s efforts in its overtime victory over New Orleans. Gibbs ran for 156 yards and two touchdowns, while St. Brown caught 10 passes, two of which were touchdowns. With superstars like Allen, Gibbs and St. Brown and more, the Bills and Lions could be involved in a high-scoring affair to kick off Week 2. Don’t miss out on the $365 bonus bets from bet365 when you use promo code FOX365. How to Sign Up and Claim the bet365 Sportsbook Bonus Code *Odds are subject to change* Anytime TD Scorer Odds More games and markets available on bet365. How to Watch Lions vs. Bills Players to Watch Buffalo’s offense already looks explosive, and Allen is the reason Detroit has to prepare for chaos on every snap. In the Bills’ Week 1 win, he threw for 320 yards and 3 touchdowns on 24 of 33 passing, then added a rushing score as Buffalo piled up 41 points and 470 total yards. Detroit allowed 30 points in its opener, even while generating 5 sacks and 3 takeaways, so Allen’s job is to keep pushing the tempo without feeding that Lions front free possessions. Sustained drives and red-zone finishes give Buffalo its clearest path to controlling this Thursday night game. When Detroit leans hard toward stopping the pass, Cook becomes Buffalo’s second hammer. He ripped off 115 rushing yards and a touchdown on 19 carries in Week 1, and the Bills averaged better than 5 yards per rush as a team in the opener. Detroit’s defense came out aggressive with 5 sacks and 3 takeaways, the kind of front that can force quarterbacks into long-yardage spots. A back who keeps the offense on schedule and wins early downs takes pressure off Allen and keeps the Lions from teeing off all night. Detroit still has enough offensive balance to push Buffalo, and Goff’s decision-making decides whether the Lions stay in the shootout. In Week 1 he threw for 225 yards and 2 touchdowns, completing 23 of 32 passes while Detroit scored 30 points. Buffalo just gave up 31 points in its opener even while forcing 2 takeaways and recording 3 sacks, so the window is there if Goff stays clean. Timing throws and avoiding the empty drives that come with negative plays keep Detroit’s offense from stalling against a Bills defense that can still flip field position. Goff’s Week 1 tone-setter in the passing game was St. Brown, and that connection is Detroit’s cleanest path to chunk plays here. He caught 8 of 10 targets for 89 yards and a touchdown in the opener, operating as the Lions’ primary rhythm receiver. Buffalo allowed 26 completions on 38 targets and 31 points in Week 1, which puts a premium on a receiver who can win early and finish drives. St. Brown giving Goff a reliable outlet on intermediate routes helps Detroit stay ahead of the chains against a Bills front that still generates pressure.
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