2025-26 Men’s Second Rounds Odds: Spreads, Lines for all 16 Games

We’re diving into the second round of basketball’s greatest Tournament. Let’s check out the odds for the men’s NCAA Tournament Round of 32 at DraftKings Sportsbook as of March 21. This page may contain affiliate links to legal sports betting partners. If you sign up or place a wager, FOX Sports may be compensated. Read more about Sports Betting on FOX Sports. SATURDAY, MARCH 21 No. 12 High Point vs. No. 4 Arkansas Spread: Arkansas -11.5Moneyline: Arkansas -700, HPU +500O/U: 168.5 No. 11 Texas vs. No. 3 Gonzaga Spread: Gonzaga -6.5Moneyline: Gonzaga -250, Texas +205O/U: 147.5 No. 11 VCU vs. No. 3 Illinois Spread: Illinois -11.5Moneyline: Illinois -550, VCU +410O/U: 151.5 No. 10 Texas A&M vs. No. 2 Houston Spread: Houston -10.5Moneyline: Houston -500, TA&M +380O/U: 142.5 No. 9 Saint Louis vs. No. 1 Michigan Spread: Michigan -12.5Moneyline: Michigan -900, SLU +600O/U: 161.5 No. 9 TCU vs. No. 1 Duke Spread: Duke -11.5Moneyline: Duke -800, TCU +550O/U: 139.5 No. 6 Louisville vs. No. 3 Michigan State Spread: MSU -4.5Moneyline: MSU -192, Louisville +160O/U: 151.5 No. 5 Vanderbilt vs. No. 4 Nebraska Spread: Vandy -1.5Moneyline: Vandy -125, Nebraska +105O/U: 146.5 SUNDAY, MARCH 22 No. 9 Utah State vs. No. 1 Arizona Spread: Arizona -11.5Moneyline: Arizona -800, Utah State +550O/U: 156.5 No. 9 Iowa vs. No. 1 Florida Spread: Florida -10.5Moneyline: Florida -600, Iowa +440O/U: 145.5 No. 7 Kentucky vs. No. 2 Iowa State Spread: Iowa State -4.5Moneyline: Iowa State -218, Kentucky +180O/U: 145.5 No. 7 UCLA vs. No. 2 UConn Spread: UConn -4.5Moneyline: UConn -205, UCLA +170O/U: 139.5 No. 6 Tennessee vs. No. 3 Virginia Spread: Tennessee -1.5Moneyline: Tennessee -118, Virginia -102O/U: 137.5 No. 5 St. John’s vs. No. 4 Kansas Spread: St. John’s -2.5Moneyline: St. John’s -148, Kansas +124O/U: 143.5 No. 5 Texas Tech vs. No. 4 Alabama Spread: Alabama -1.5Moneyline: Alabama -112, Texas Tech -108O/U: 165.5